Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar).

Unusual pulmonary reaction during short term prophylaxis with pyrimethamine-sulfadoxine (Fansidar).

'Klemp P, Staberg B, Madsbad S, Kolcndorf K. Smoking reduces insulin absorption from subcutaneous tissue. Br MedJ' 1982;284:237. 2 Binder C. Absorption of injected insulin. Acta Pharmacol Toxicol (Copenh) 1969 ;27(suppl 2): 1-84. 3Berger M, Cuppers HJ, Hegner H, Jorgens V, Berchtold P. Absorption kinetics and biologic effects of subcutaneously injected insulin preparations. Diabetes Care 1982;5...

Sulfadoxine-Pyrimethamine Combination in Congenital Toxoplasmosis.

Antimalarial efficacy of sulfadoxine-pyrimethamine, amodiaquine and a combination of chloroquine plus sulfadoxine-pyrimethamine in Bundi Bugyo, western Uganda.

We report below an in vivo antimalarial efficacy study conducted in 2002 in Bundi Bugyo, a district of western Uganda housing a large displaced population. We tested sulfadoxine-pyrimethamine (SP), amodiaquine (AQ) and the combination chloroquine plus SP (CQ + SP). A total of 268 children with uncomplicated Plasmodium falciparum malaria were followed-up for 28 days according to WHO recommendati...

Sulfadoxine-pyrimethamine resistance in the rodent malaria parasite Plasmodium chabaudi.

We have studied resistance to sulfadoxine-pyrimethamine (S/P) in the rodent malaria parasite Plasmodium chabaudi. A stable S/P-resistant mutant, AS(50S/P), was selected by drug treatment of a clone, AS(PYR), already resistant to pyrimethamine. The sequences of the P. chabaudi dhfr and dhps genes were obtained and found to be identical in AS(50S/P) and AS(PYR), showing that resistance to S/P in ...

Evolution of resistance to sulfadoxine-pyrimethamine in Plasmodium falciparum.

The development of resistance to sulfadoxine-pyrimethamine by Plasmodium parasites is a major problem for the effective treatment of malaria, especially P. falciparum malaria. Although the molecular basis for parasite resistance is known, the factors promoting the development and transmission of these resistant parasites are less clear. This paper reports the results of a quantitative compariso...